Brief Introduction

Message from author (3.31, 2020): All bugs previously reported by users have been repaired. Thanks for your support and use!

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Traditional Chinese Medicine (TCM), with a history of thousands of years of clinical practice, plays an important role in maintaining the health of peoples of Asia, and is gaining more and more application all over the world. However, owing to the diversity of TCM’s ingredients and the complexity of TCM’s interaction with human body, it is still quite difficult to uncover the underlying molecular mechanism of TCM. The clarification of the TCM’s molecular mechanism has become a bottleneck in TCM modernization and internationalization. BATMAN-TCM (a Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine) is the first online bioinformatics analysis tool specially designed for the research of molecular mechanism of TCM.

For user-submitted TCM, BATMAN-TCM will first predict potential targets for each query TCM’s ingredient, and then perform functional analyses on these targets including Gene Ontology (GO) term, KEGG pathway and OMIM/TTD disease enrichment analyses. TCM ingredient-target-pathway/disease association network and biological pathway with highlighted TCM’s targets will also be shown. These functions aim to contribute to the understanding of the “multi-component, multi-target and multi-pathway” combinational therapeutic mechanism of TCM and to provide clues for the following experimental validation. In addition, BATMAN-TCM also supports users to simultaneously input multiple TCMs, which is typically used to simultaneously analyze multiple compositive herbs of a formula, helping understand this combinational principle of a formula from molecular and systematic level.

Please see “Tutorials” for more information.

Every user’s submitted data will be kept private and not viewable by anyone other than the user or those given permission by the user.

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Related web server

!!!Announcement(2023-10-08): We are very happy to announce that the BATMAN-TCM database has been updated to version 2.0! Please visit our website to explore the new features. Any comments are welcome. (liuchao_2022@126.com).

1. Please input the interested TCM

Example 1

Example 2

Example 3

Example 4

Cluster name:

Cluster1

Select input type:

Formula (Pinyin name) Herb or Herb list (Pinyin/Latin/English name) Compound list (PubChem_CID/InChI)

*Formula (Pinyin name):

Cluster name:

Cluster2

Select input type:

Formula (Pinyin name) Herb or Herb list (Pinyin/Latin/English name) Compound list (PubChem_CID/InChI)

*Formula (Pinyin name):

Cluster name:

Cluster3

Select input type:

Formula (Pinyin name) Herb or Herb list (Pinyin/Latin/English name) Compound list (PubChem_CID/Inchi)

*Formula (Pinyin name):

Cluster name:

Cluster4

Select input type:

Formula (Pinyin name) Herb or Herb list (Pinyin/Latin/English name) Compound list (PubChem_CID/InChI)

*Formula (Pinyin name):

Add one cluster Delete the last cluster

* Required Field.

Annotation
Three alternative input types: TCM formula (Pinyin name) (e.g. JIA WEI CAN XIA TANG), Herb or Herb list (Pinyin, English or Latin name) (e.g. ren shen, Ginseng or Panax ginseng) or User defined compositive compound list of the TCM (compounds are denoted by PubChem_CIDs or chemical structures of InChI format). For the second and third input types, multiple herbs/compounds are supported, one herb/compound per line.
For the third input type, currently only PubChem_CID or InChI format is supported. If you have compound lists represented by other types of format, you can use OpenBabel to transfer the format.
By clicking on “Add one cluster”, BATMAN-TCM also supports users to simultaneously input multiple TCM formulas/herbs/Compound lists. Please click on “Example 4” to obtain an example (4 clusters maximum).

2. Parameters setting

Target Prediction

For each compositive compound, the predicted candidate targets whose scores given by the target prediction method exceed a given cutoff "Score cutoff " (including known targets) will be considered as the potential targets, and will be presented and further analyzed.

Input parameter Score cutoff:

10 15 18 20 23 25 26 30 35 39 48 55 80 100 114 120 124 130 140 160 180 250 350 500 700 1000

Target Analyses

The significantly enriched Gene Ontology functional terms, KEGG biological pathways and OMIM/TTD diseases among the potential targets of the query TCM are analyzed. (During the enrichment analyses, we only consider the predicted candidate targets (including known targets) with scores no smaller than 20 as you set above.)

Please set the cutoff of P-value after Benjamini-Hochberg multiple testing correction (Adjusted P-value) :

3. Now start to predict and analyze

Attention: When the user selects the input type of “compound list”, the E-mail notification function below is highly recommended, because the analyses of the submitted “compound list” generally consume much time. Conservatively a compound averagely consumes about 5 mins.

E-mail Notification [Optional]
(If you select this function, two E-mails will be sent to you. The first one is sent to you after your job is submitted, in which a web link will be provided to help you check the progress of your job and the analysis results at any time. If you can't receive this E-mail in ten minutes, please check you spam mail just in case. The second one is sent to you when your job is fininshed.)

Your E-mail:

Start Reset

Please cite: Kong X, Liu C, Zhang Z, Cheng M, Mei Z, Li X, Liu P, Diao L; Ma Y, Jiang P; Kong X, Nie S, Guo Y, Wang Z, Zhang X, Wang Y, Tang L, Guo S, Liu Z, Li D. BATMAN-TCM 2.0: an enhanced integrative database for known and predicted linkages between traditional Chinese medicine ingredients and target proteins. Nucleic Acids Research. (10.1093/nar/gkad926)